The Darkmoon Zepp takes out the python easily, I open with Bomb the drop the target dummies then just spam missle, The zepp usually takes a beating from his poison but he never dies. And the bomb going off ususally kills him and if something misses then the first missle after the bomb gets him.
"Even when you are winning soundly, you must always give your opponent a way to retreat with honor. If you don't, then he has no reason to surrender. He will fight until the bitter end, and you will pay a larger price for victory."